KLF8 Gene Summary [Human]
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Details
| Type | Retained Intron |
| Official Symbol | KLF8 |
| Official Name | Kruppel like factor 8 [Source:HGNC Symbol;Acc:HGNC:6351] |
| Ensembl ID | ENSG00000102349 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 8, KLF transcription factor 8 |
| Synonyms | A830097P10RIK, BKLF3, Klf8-ps1, KLF transcription factor 8, Kruppel-like transcription factor 8, LOC105373216, RGD1565831, ZNF74, ZNF741 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
- nucleic acid binding
- C2H2-type zinc-finger domain
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
Pathways
Biological processes and signaling networks where the KLF8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic ovarian cancer
- tumorigenesis
- breast carcinoma
- alopecia
- invasive ovarian cancer
role in cell
- activation in
- proliferation
- expression in
- cell viability
- cell death
- quantity
- phosphorylation in
- transactivation in
- invasion by
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- aggresome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity