PRKAB1 Gene Summary [Human]
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRKAB1 |
| Official Name | protein kinase AMP-activated non-catalytic subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:9378] |
| Ensembl ID | ENSG00000111725 |
| Bio databases IDs | |
| Aliases | protein kinase AMP-activated non-catalytic subunit beta 1, AMPK beta 1 |
| Synonyms | 1300015D22Rik, AMPK, AMPK beta 1, AMPK β 1, E430008F22, HAMPKb, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase AMP-activated non-catalytic subunit beta 1, protein kinase AMP-activated non-catalytic subunit β 1, protein kinase, AMP-activated, β 1 non-catalytic subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKAB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- E_set
- glycogen binding domain
- protein kinase
- Glycogen recognition site of AMP-activated protein kinase
- protein kinase binding
- 5'-AMP-activated protein kinase beta subunit, interaction domain
- protein binding
- SNF1A/AMP-activated protein kinase
Pathways
Biological processes and signaling networks where the PRKAB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Mitochondrial Dysfunction
- mTOR Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- impaired glucose tolerance
- neoplasia
- obesity
- epithelial cancer
- epithelial neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- colorectal adenocarcinoma
role in cell
- growth
- expression in
- phosphorylation in
- production in
- apoptosis
- aggregation
- formation in
- function
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKAB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- signal transduction
- positive regulation of gene expression
- nail development
- fatty acid biosynthetic process
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- AMP-activated protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein kinase activity