AIMP1 Gene Summary [Human]
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | AIMP1 |
| Official Name | aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [Source:HGNC Symbol;Acc:HGNC:10648] |
| Ensembl ID | ENSG00000164022 |
| Bio databases IDs | |
| Aliases | aminoacyl tRNA synthetase complex interacting multifunctional protein 1, EMAP II, ARS-interacting multifunctional protein 1, multisynthetase complex auxiliary component p43 |
| Synonyms | 9830137A06RIK, AIMP1/p43, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1, EMAP2, EMAPII, endothelial monocyte-activating polypeptide, HLD3, p43, SCYE1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AIMP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- enzyme binding
- protein homodimerization
- protein binding
- tRNA_bindingDomain
- cytokine
- Cell division protein ZapB
- Putative tRNA binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- hypomyelinating leukodystrophy type 3
- severe acute respiratory syndrome
- tuberculoid leprosy
- male pattern hair loss
role in cell
- proliferation
- survival
- migration
- apoptosis
- growth
- formation
- accumulation
- cell division
- network formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- cell surface
- intracellular space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AIMP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- positive regulation of glucagon secretion
- signal transduction
- angiogenesis
- apoptotic process
- cell-cell signaling
- defense response to virus
- negative regulation of endothelial cell proliferation
- leukocyte migration
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- membrane
- cytosol
- Golgi apparatus
- aminoacyl-tRNA synthetase multienzyme complex
- endoplasmic reticulum
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- GTPase binding
- cytokine activity
- tRNA binding