HSPA4L Gene Summary [Human]
The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | HSPA4L |
| Official Name | heat shock protein family A (Hsp70) member 4 like [Source:HGNC Symbol;Acc:HGNC:17041] |
| Ensembl ID | ENSG00000164070 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 4 like |
| Synonyms | AC146980.1, APG-1, heat shock protein 4 like, heat shock protein family A (Hsp70) member 4 like, HSPH3, OSP94 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA4L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP binding
- protein binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA4L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- oligozoospermia
- ulcerative colitis
- hydronephrosis
- hypercalcemia
- weight loss
- COVID-19
- androgenic alopecia
- asthenozoospermia
regulates
- Na+
- blood urea nitrogen
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA4L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein folding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- adenyl-nucleotide exchange factor activity