WDR41 Gene Summary [Human]
Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex. Colocalizes with Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | WDR41 |
| Official Name | WD repeat domain 41 [Source:HGNC Symbol;Acc:HGNC:25601] |
| Ensembl ID | ENSG00000164253 |
| Bio databases IDs | |
| Aliases | WD repeat domain 41 |
| Synonyms | B830029I03Rik, MSTP048, WD repeat domain 41 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- guanyl-nucleotide exchange factor
- WD domain, G-beta repeat
- WD40
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- regulation of autophagy
- negative regulation of immune response
- positive regulation of GTPase activity
- negative regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- guanyl-nucleotide exchange factor complex
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity