CXADR Gene Summary [Human]
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | CXADR |
| Official Name | CXADR Ig-like cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:2559] |
| Ensembl ID | ENSG00000154639 |
| Bio databases IDs | |
| Aliases | CXADR Ig-like cell adhesion molecule |
| Synonyms | 2610206D03RIK, AU016810, CAR, CAR4/6, COXSACKIE VIRUS and ADENOVIRUS receptor, CXADR Ig-like cell adhesion molecule, CXADR, Ig-like cell adhesion molecule, HCAR, MCAR, MCVADR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXADR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- beta-catenin binding
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- ectodomain
- TM_EGFR-like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- identical protein binding
- PDZ-domain binding
- cytoplasmic domain
- integrin binding
- Immunoglobulin like
- immunoglobulin-like protein domain
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the CXADR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- endometriosis
- diabetic nephropathy
- edema
- organismal death
- cardiac hyperplasia
- hemopericardium
- gastroesophageal reflux
- pericardial effusion
- ovarian carcinoma
role in cell
- expression in
- activation in
- proliferation
- binding
- chemotaxis
- apoptosis
- formation
- growth
- development
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- apicolateral membrane
- glutaminergic synapse
- cell junction
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- presynaptic membrane
- caveolae
- basolateral membrane
- nucleoplasm
- acrosome
- neuromuscular junctions
- growth cone
- neurites
- synapse
- intercalated disks
- sarcolemma
- anchoring junction
- tight junctions
- membrane rafts
- filopodia
- perikaryon
- axons
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXADR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- AV node cell to bundle of His cell communication
- gamma-delta T cell activation
- heterophilic cell-cell adhesion
- germ cell migration
- cell-cell junction organization
- mitochondrion organization
- heart development
- epithelial structure maintenance
- cardiac muscle cell development
- transepithelial transport
- neutrophil chemotaxis
- AV node cell-bundle of His cell adhesion involved in cell communication
- homotypic cell-cell adhesion
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- extracellular region
- neuron projection
- plasma membrane
- nucleoplasm
- growth cone
- tight junction
- adherens junction
- cell-cell junction
- cytoplasm
- acrosomal vesicle
- cell body
- membrane raft
- filopodium
- intercalated disc
- cell junction
- macromolecular complex
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- connexin binding
- cell adhesion molecule binding
- PDZ domain binding
- cell adhesive protein binding involved in AV node cell-bundle of His cell communication
- integrin binding
- viral receptor activity
- beta-catenin binding