HTR4 Gene Summary [Human]
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | HTR4 |
| Official Name | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] |
| Ensembl ID | ENSG00000164270 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 4 |
| Synonyms | 5-HT, 5-HT-4, 5-HT4R, 5HTR4, 5-hydroxytryptamine receptor 4, 5 hydroxytryptamine (serotonin) receptor 4, Serotonin receptor 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Taste receptor protein (TAS2R)
- Cholecystokinin A receptor, N-terminal
- serotonin receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- migraines
- anorexia
- obesity
- migraine variant
- diabetic gastroparesis
- diabetes mellitus
- visceral hypersensitive reaction
- chronic obstructive pulmonary disease
- dyspepsia
regulated by
- BIMU 8
- tegaserod
- beta-estradiol
- 5-methoxytryptamine
- ZFPM1
- 5-hydroxytryptamine
- renzapride
- GRK
- SL-650155
- RS 67333
role in cell
- activity
- expression in
- production in
- quantity
- replication in
- formation in
- number
- expansion
- maintenance
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- somatodendritic region
- postsynaptic region
- cellular membrane
- dense granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of appetite
- mucus secretion
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- maintenance of gastrointestinal epithelium
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- endosome
- cytoplasm
- membrane
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity