Htr4 Gene Summary [Rat]
Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and postsynapse. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr4 |
| Official Name | 5-hydroxytryptamine receptor 4 [Source:RGD Symbol;Acc:2850] |
| Ensembl ID | ENSRNOG00000019134 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 4 |
| Synonyms | 5-HT, 5-HT-4, 5-HT4R, 5HTR4, 5-hydroxytryptamine receptor 4, 5 hydroxytryptamine (serotonin) receptor 4, Serotonin receptor 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Taste receptor protein (TAS2R)
- Cholecystokinin A receptor, N-terminal
- serotonin receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- migraines
- anorexia
- obesity
- migraine variant
- diabetic gastroparesis
- diabetes mellitus
- visceral hypersensitive reaction
- chronic obstructive pulmonary disease
- dyspepsia
regulated by
- BIMU 8
- tegaserod
- beta-estradiol
- 5-methoxytryptamine
- ZFPM1
- 5-hydroxytryptamine
- renzapride
- GRK
- SL-650155
- RS 67333
role in cell
- activity
- expression in
- production in
- quantity
- replication in
- formation in
- number
- expansion
- maintenance
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- somatodendritic region
- postsynaptic region
- cellular membrane
- dense granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of appetite
- mucus secretion
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- maintenance of gastrointestinal epithelium
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- endosome
- cytoplasm
- membrane
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity