DAGLB Gene Summary [Human]
Enables lipase activity. Involved in arachidonic acid metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | DAGLB |
| Official Name | diacylglycerol lipase beta [Source:HGNC Symbol;Acc:HGNC:28923] |
| Ensembl ID | ENSG00000164535 |
| Bio databases IDs | |
| Aliases | diacylglycerol lipase beta |
| Synonyms | DAGLBETA, diacylglycerol lipase beta, diacylglycerol lipase, beta, diacylglycerol lipase β, diacylglycerol lipase, β, E330036I19Rik, KCCR13L, LOC221955, RGD1310193 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAGLB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- acylglycerol lipase
- lipase
- enzyme
- protein binding
- Lipase (class 3)
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the DAGLB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic fibrosis
- autosomal recessive early-onset Parkinson disease
- cholelithiasis
- gallstone
- autosomal recessive spastic paraplegia type 47
- osteoarthritis
- coronary artery disease
regulates
- arachidonic acid
- triacylglycerol
- prostaglandin
- 2-arachidonoylglycerol
- eicosanoid
- monoacylglycerol
role in cell
- proliferation
- neurogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAGLB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- diacylglycerol catabolic process
- neuroblast proliferation
- prostaglandin biosynthetic process
- monoacylglycerol biosynthetic process
- regulation of inflammatory response
- neurogenesis
- positive regulation of triglyceride catabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- lysosomal membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acylglycerol lipase activity
- protein binding
- metal ion binding
- triglyceride lipase activity
- lipase activity