RXFP1 Gene Summary [Human]
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | RXFP1 |
| Official Name | relaxin family peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:19718] |
| Ensembl ID | ENSG00000171509 |
| Bio databases IDs | |
| Aliases | relaxin family peptide receptor 1 |
| Synonyms | Gm1018, LGR7, relaxin family peptide receptor 1, relaxin/insulin-like family peptide receptor 1, RXFPR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RXFP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- hormone binding
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- calcium binding loop
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane domain
- LDLa
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the RXFP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- acute lymphoblastic leukemia
- systemic sclerosis
- congestive heart failure
- pulmonary fibrosis
- cryptorchidism
- azoospermia
regulates
- cyclic AMP
- ACTA2
- synthetic promoter
- Seap reporter gene
- ADCY
role in cell
- expression in
- migration
- differentiation
- organization
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RXFP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
- lung connective tissue development
- nipple morphogenesis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- activation of adenylate cyclase activity
- hormone-mediated signaling pathway
- parturition
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- metal ion binding
- hormone binding