SAP30L Gene Summary [Human]
Enables several functions, including non-sequence-specific DNA binding activity, bending; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SAP30L |
| Official Name | SAP30 like [Source:HGNC Symbol;Acc:HGNC:25663] |
| Ensembl ID | ENSG00000164576 |
| Bio databases IDs | |
| Aliases | SAP30 like |
| Synonyms | 2310079P12Rik, L55, LOC56755, LOC56757, NS4ATP2, RGD1309585, SAP30-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SAP30L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- SAP30 zinc-finger
- binding protein
- zinc ion binding
- DNA bending protein
- chromatin binding
- protein binding
- Sin3 binding region of histone deacetylase complex subunit SAP30
- phosphatidylinositol binding
- DNA binding
Pathways
Biological processes and signaling networks where the SAP30L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SAP30L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone deacetylase complex
- nucleolus
- fibrillar center
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- transcription cofactor activity
- protein binding
- histone binding
- nucleosome binding
- phosphatidylinositol-5-phosphate binding
- non-sequence-specific DNA binding, bending