ING2 Gene Summary [Human]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | ING2 |
| Official Name | inhibitor of growth family member 2 [Source:HGNC Symbol;Acc:HGNC:6063] |
| Ensembl ID | ENSG00000168556 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family member 2 |
| Synonyms | 2810011M06Rik, ING1L, Ing2b, inhibitor of growth family member 2, inhibitor of growth family, member 2, P33ING2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ING2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- histone binding
- PHD zinc finger
- transcription regulator
- cysteine-rich zinc-binding domain
- protein binding activity, bridging
- chromatin binding
- Phosphatidylinositol binding domain
- protein binding
- phosphatidylinositol binding
- DNA binding
- binding protein
- Inhibitor of growth (ING) domain family
- PHD finger superfamily
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- globozoospermia
- hyperplasia
- oligozoospermia
- asthenozoospermia
- neoplastic histiocytosis
- hematologic cancer
- hematological neoplasia
- teratozoospermia
role in cell
- apoptosis
- expression in
- growth
- transcription in
- acetylation in
- production in
- number
- function
- formation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasmic fraction
- nuclear matrix fraction
- Cytoplasm
- Plasma Membrane
- nuclear foci
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ING2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- signal transduction
- spermatid development
- spermatogenesis
- male meiosis I
- regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- negative regulation of transcription from RNA polymerase II promoter
- male germ-line stem cell division
- sperm motility
- seminiferous tubule development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell migration
- regulation of cellular senescence
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
- plasma membrane
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- histone deacetylase regulator activity
- DNA binding
- protein binding
- metal ion binding
- methylated histone residue binding
- phosphatidylinositol binding
- chromatin binding