FRAT1 Gene Summary [Human]
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | FRAT1 |
| Official Name | FRAT regulator of WNT signaling pathway 1 [Source:HGNC Symbol;Acc:HGNC:3944] |
| Ensembl ID | ENSG00000165879 |
| Bio databases IDs | |
| Aliases | FRAT regulator of WNT signaling pathway 1 |
| Synonyms | FRAT regulator of WNT signaling pathway 1, frequently rearranged in advanced T cell lymphomas, GBP, LOC100911460 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycogen synthase kinase-3 binding
- protein binding
Pathways
Biological processes and signaling networks where the FRAT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- atrial fibrillation
- nephrosis
- focal segmental glomerulosclerosis
- severe acute respiratory syndrome
role in cell
- phosphorylation in
- cell death
- apoptosis
- proliferation
- migration
- invasion by
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- cytoplasmic particles
- cytosol
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of canonical Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- regulation of protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding