FRAT2 Gene Summary [Human]
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FRAT2 |
| Official Name | FRAT regulator of WNT signaling pathway 2 [Source:HGNC Symbol;Acc:HGNC:16048] |
| Ensembl ID | ENSG00000181274 |
| Bio databases IDs | |
| Aliases | FRAT regulator of WNT signaling pathway 2, GSK-3 binding protein FRAT2 |
| Synonyms | FRAT regulator of WNT signaling pathway 2, frequently rearranged in advanced T cell lymphomas 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRAT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycogen synthase kinase-3 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- atrial fibrillation
- migraines
- fibrosis
role in cell
- migration
- invasion by
- phosphorylation in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRAT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- canonical Wnt receptor signaling pathway
- regulation of protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol