QSOX2 Gene Summary [Human]
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | QSOX2 |
| Official Name | quiescin sulfhydryl oxidase 2 [Source:HGNC Symbol;Acc:HGNC:30249] |
| Ensembl ID | ENSG00000165661 |
| Bio databases IDs | |
| Aliases | quiescin sulfhydryl oxidase 2, thiol oxidase 2 |
| Synonyms | BC030934, LOC103691753, LOC687383, QSCN6L1, quiescin Q6 sulfhydryl oxidase 2, quiescin Q6 sulphydryl oxidase 2, quiescin sulfhydryl oxidase 2, quiescin sulphydryl oxidase 2, SOXN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human QSOX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- QSOX Trx-like domain
- Erv1 / Alr family
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human QSOX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein folding
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular space
- Golgi apparatus
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein disulfide isomerase activity
- flavin-linked sulfhydryl oxidase activity