EEF1G Gene Summary [Human]
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EEF1G |
| Official Name | eukaryotic translation elongation factor 1 gamma [Source:HGNC Symbol;Acc:HGNC:3213] |
| Ensembl ID | ENSG00000254772 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 gamma |
| Synonyms | 2610301D06RIK, EEF1B gamma, EEF1B γ, Eef1 γ, EF1G, EF-1 gamma, EF-1 γ, ELONGATION FACTOR 1 gamma, ELONGATION FACTOR 1 γ, eukaryotic translation elongation factor 1 gamma, eukaryotic translation elongation factor 1 γ, GIG35 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF1G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Elongation factor 1 gamma, conserved domain
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Nucleus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF1G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to virus
- translational elongation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation elongation factor activity
- cadherin binding