Bag5l1 Gene Summary [Rat]
Enables protein-folding chaperone binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of protein refolding; negative regulation of ubiquitin-protein transferase activity; and regulation of inclusion body assembly. Predicted to be located in inclusion body; mitochondrion; and perinuclear region of cytoplasm. Predicted to be part of junctional membrane complex. Predicted to be active in cytosol; membrane; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2F. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bag5l1 |
| Official Name | BCL2-associated athanogene 5-like 1 [Source:RGD Symbol;Acc:9457021] |
| Ensembl ID | ENSRNOG00000058841 |
| Bio databases IDs | |
| Aliases | BCL2-associated athanogene 5-like 1 |
| Synonyms | 1600025G07Rik, 4930405J06Rik, Bag5l1, BAG cochaperone 5, BCL2-associated athanogene 5, CMD2F |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bag5l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- BAG domains, present in regulator of Hsp70 proteins
- protein kinase binding
- enzyme inhibitor activity
- BAG domain
- protein binding
- enzyme regulator activity
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy type 2F
- peripheral arterial disease
- neurodegeneration
- cardiomyopathy
role in cell
- cell death
- apoptosis
- development
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- junctional membrane complex
- intracellular space
- perinuclear region
- Nucleus
- Mitochondria
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bag5l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ubiquitin-protein ligase activity
- negative regulation of neuron projection development
- Golgi organization
- negative regulation of protein ubiquitination
- negative regulation of protein refolding
- protein stabilization
- regulation of inclusion body assembly
- protein folding
- regulation of ubiquitin-protein ligase activity
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- mitochondrion
- cytosol
- inclusion body
- junctional membrane complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin protein ligase binding
- chaperone binding
- adenyl-nucleotide exchange factor activity