ASPG Gene Summary [Human]
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and lysophospholipase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ASPG |
| Official Name | asparaginase [Source:HGNC Symbol;Acc:HGNC:20123] |
| Ensembl ID | ENSG00000166183 |
| Bio databases IDs | |
| Aliases | asparaginase, 60-kDa-lysophospholipase |
| Synonyms | A530050D06Rik, asparaginase, C14orf76, Gm690, GPA/WT, hASNase1, LOC246266, LYSOLP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASPG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Bacterial L-asparaginases and related enzymes
- lysophospholipase
- asparaginase
- Ankyrin repeats (3 copies)
- enzyme
- protein binding
- Ankyrin repeat
- 1-alkyl-2-acetylglycerophosphocholine esterase
- Glutaminase/Asparaginase C-terminal domain
- glutamyl-tRNA(Gln) amidotransferase, subunit D
- Non-amino-acyl group acyltransferase
- Asparaginase, N-terminal
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASPG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aspartate family amino acid metabolic process
- lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- transferase activity, transferring acyl groups other than amino-acyl groups
- protein binding
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- asparaginase activity