SHC3
SHC3 Gene Summary
Enables phosphotyrosine residue binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SHC3 |
| Official Name | SHC adaptor protein 3 [Source:HGNC Symbol;Acc:HGNC:18181] |
| Ensembl ID | ENSG00000148082 |
| Bio databases IDs | |
| Aliases | SHC adaptor protein 3 |
| Synonyms | NSHC,Nsrc,RAI,SHC adaptor protein 3,SHCC,src homology 2 domain-containing transforming protein C3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- CH1 domain
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- receptor binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- protein-tyrosine kinase
- Grb2 binding domain
Pathways
Biological processes and signaling networks where the SHC3 gene plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Breast Cancer Regulation by Stathmin1
- CREB Signaling in Neurons
- Endothelin-1 Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Gαi Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- NGF Signaling
- Renin-Angiotensin Signaling
- Role of NFAT in Cardiac Hypertrophy
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ERBB2
- AR
- EGFR
- PSMD8
- VPS28
- APP
- WWOX
- KRT31
- EWSR1
- CCNC
disease
- androgenic alopecia
- neurological deficiency
- infarction
- Cornelia de Lange syndrome
- pemphigus vulgaris
regulated by
- RET
- EGF
- GDNF
- S100A9
- S100A8
- neurotrophin
- NTRK2
- SRC
- PTP4A1
- NTF3
regulates
- ERBB2
- ERK1/2
- PI3K (complex)
- AKT
- AKT1
- TCR (complex)
- APP
- SRC
- MAPK
- ZAP70
role in cell
- expression in
- phosphorylation in
- growth
- loss
- differentiation
- apoptosis
- quantity
- survival
- signal transduction in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- Plasma Membrane
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SHC3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- central nervous system development
- epidermal growth factor receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- intracellular signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- receptor tyrosine kinase binding