TMED3 Gene Summary [Human]
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMED3 |
| Official Name | transmembrane p24 trafficking protein 3 [Source:HGNC Symbol;Acc:HGNC:28889] |
| Ensembl ID | ENSG00000166557 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 3 |
| Synonyms | 1200002G13Rik, C15orf22, Gamma4 p24 family, INTEGRAL type1, MGC94283, P24B, P24 Beta1, p24g4, p24gamma4, p26, transmembrane p24 trafficking protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMED3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- emp24/gp25L/p24 family/GOLD
- sorting signal domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- perinuclear Golgi regions
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- cis Golgi networks
- transport vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMED3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- Golgi organization
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi cisterna membrane
- Golgi membrane
- ER to Golgi transport vesicle
- endoplasmic reticulum
- Golgi apparatus
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment
- COPI vesicle coat
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- cargo receptor activity