BLZF1 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Acts upstream of or within Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus and nucleoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BLZF1 |
| Official Name | basic leucine zipper nuclear factor 1 [Source:HGNC Symbol;Acc:HGNC:1065] |
| Ensembl ID | ENSG00000117475 |
| Bio databases IDs | |
| Aliases | basic leucine zipper nuclear factor 1, golgin-45 |
| Synonyms | 1700030G05RIK, basic leucine zipper nuclear factor 1, BLZF1L, GOLGIN-45, JEM-1, JEM-1s |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BLZF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- transcription regulator
- enzyme binding
- protein binding
- DASH complex subunit Hsk3 like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- Nucleus
- Golgi Apparatus
- Golgi membrane
- nucleoplasm
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BLZF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi organization
- Golgi to plasma membrane protein transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cis-Golgi network
- cytoplasm
- Golgi apparatus
- Golgi membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- enzyme binding