ARFGAP1 Gene Summary [Human]
The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | ARFGAP1 |
| Official Name | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] |
| Ensembl ID | ENSG00000101199 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor GTPase activating protein 1 |
| Synonyms | ARF1GAP, Arfgap, ARF GTPase activating protein 1, HRIHFB2281 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARFGAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- Putative GTP-ase activating proteins for the small GTPase, ARF
- non-catalytic domain
- GTPase activator
- enzyme
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- pigmented villonodular synovitis
role in cell
- formation
- binding
- shortening
- release
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- synapse
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARFGAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein transport
- regulation of ARF protein signal transduction
- regulation of endocytosis
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi membrane
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity