NNMT Gene Summary [Human]
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NNMT |
| Official Name | nicotinamide N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:7861] |
| Ensembl ID | ENSG00000166741 |
| Bio databases IDs | |
| Aliases | nicotinamide N-methyltransferase |
| Synonyms | NICOTINAMIDE N-METHYLTRANSFERASE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NNMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- nicotinamide n-methyltransferase
- enzyme
- AdoMet_MTases
- pyridine N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- gastroesophageal junction adenocarcinoma
- non-insulin-dependent diabetes mellitus
- neoplasia
- osteoporosis
- end stage renal disease
- heart disease
- atherosclerosis
- oral squamous cell carcinoma
- dyslipidemia
role in cell
- expression in
- proliferation
- migration
- gluconeogenesis in
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NNMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nicotinamide metabolic process
- positive regulation of protein deacetylation
- NAD biosynthesis via nicotinamide riboside salvage pathway
- organ regeneration
- response to xenobiotic stimulus
- response to organic nitrogen
- positive regulation of gluconeogenesis
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- nicotinamide N-methyltransferase activity
- pyridine N-methyltransferase activity