CIAO2A
CIAO2A Gene Summary
Predicted to enable metal ion binding activity. Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytosol and nucleoplasm. Part of CIA complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CIAO2A |
| Official Name | cytosolic iron-sulfur assembly component 2A [Source:HGNC Symbol;Acc:HGNC:26235] |
| Ensembl ID | ENSG00000166797 |
| Bio databases IDs | |
| Aliases | cytosolic iron-sulfur assembly component 2A |
| Synonyms | 5730536A07Rik,CIA2A,cytosolic iron-sulfur assembly component 2A,cytosolic iron-sulphur assembly component 2A,FAM96A,RGD1307481 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Iron-sulfur cluster assembly protein
- protein binding
Pathways
Biological processes and signaling networks where the CIAO2A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DOCK7
- VPS41
- KIF20A
- UCKL1
- IREB2
- ERGIC3
- HNRNPD
- TOP3B
- SIN3A
- NR1D1
disease
- IgA nephropathy
- cystitis
regulated by
- MYC
- dihydrotestosterone
regulates
- ACO1
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CIAO2A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chromosome segregation
- iron-sulfur cluster assembly
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- metal ion binding