MAPRE2 Gene Summary [Human]
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAPRE2 |
| Official Name | microtubule associated protein RP/EB family member 2 [Source:HGNC Symbol;Acc:HGNC:6891] |
| Ensembl ID | ENSG00000166974 |
| Bio databases IDs | |
| Aliases | microtubule associated protein RP/EB family member 2, APC-binding protein EB1 |
| Synonyms | C820009F03RIK, CSCSC2, D18Abb1e, EB1, EB2, LOC100911918, microtubule associated protein RP/EB family member 2, microtubule-associated protein, RP/EB family, member 2, RP1, T-CELL ACTIVATION |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAPRE2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calponin homology domain
- protein kinase binding
- calponin homology (CH) domain superfamily
- microtubule plus-end binding
- leucine zipper domain
- protein binding
- identical protein binding
- EB1-like C-terminal motif
Pathways
Biological processes and signaling networks where the MAPRE2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital symmetric circumferential skin creases type 2
- idiopathic scoliosis
- Brugada syndrome
- developmental disorder
regulates
- F Actin
- ACTIN
- APC
- GTPase
role in cell
- migration
- disassembly
- turnover in
- turnover
- stabilization in
- stabilization
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- focal adhesions
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAPRE2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle assembly
- protein localization to microtubule
- positive regulation of ARF protein signal transduction
- regulation of microtubule polymerization or depolymerization
- positive regulation of keratinocyte migration
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- spindle midzone
- microtubule cytoskeleton
- focal adhesion
- microtubule organizing center
- microtubule plus end
- cytoplasm
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- microtubule plus-end binding
- microtubule binding