GPRC5B Gene Summary [Human]
This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | GPRC5B |
| Official Name | G protein-coupled receptor class C group 5 member B [Source:HGNC Symbol;Acc:HGNC:13308] |
| Ensembl ID | ENSG00000167191 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor class C group 5 member B |
| Synonyms | G protein-coupled receptor class C group 5 member B, G protein-coupled receptor, class C, group 5, member B, G protein-coupled receptor, family C, group 5, member B, Loc293546, MLC3, RAIG-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPRC5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- protein kinase activator
- protein kinase binding
- protein kinase inhibitor activity
- G-protein-coupled receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPRC5B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute kidney injury
- weight gain
- megalencephalic leukoencephalopathy with subcortical cysts 3
- colon adenocarcinoma
- colon epithelial cancer
- rotator cuff injury
role in cell
- growth
- development
- differentiation
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cytosol
- nucleoplasm
- nucleoli
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPRC5B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macrophage cytokine production
- G-protein coupled receptor signaling pathway
- positive regulation of protein tyrosine kinase activity
- positive regulation of inflammatory response
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of neuron differentiation
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- receptor complex
- nucleolus
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- G-protein coupled receptor activity
- protein kinase binding
- protein kinase activator activity