RAB4B Gene Summary [Human]
Predicted to enable G protein activity and GTP binding activity. Involved in glucose import. Located in insulin-responsive compartment; perinuclear region of cytoplasm; and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB4B |
| Official Name | RAB4B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9782] |
| Ensembl ID | ENSG00000167578 |
| Bio databases IDs | |
| Aliases | RAB4B, member RAS oncogene family, ras-related GTP-binding protein 4b, small GTP binding protein RAB4B |
| Synonyms | 1500031G17Rik, RAB4B, member RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAB4B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- perinuclear region
- secretory granule membrane
- endosomal membrane
- synaptic vesicles
- recycling endosomes
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- Rab protein signal transduction
- protein transport
- glucose import
- endosomal vesicle fusion
- regulation of endocytosis
- early endosome to Golgi transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- secretory granule membrane
- perinuclear region of cytoplasm
- insulin-responsive compartment
- cytosol
- recycling endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity