TRAPPC9 Gene Summary [Human]
This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | TRAPPC9 |
| Official Name | trafficking protein particle complex 9 [Source:HGNC Symbol;Acc:HGNC:30832] |
| Ensembl ID | ENSG00000167632 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 9, trafficking protein particle complex subunit 9, TRAPP 120 kDa subunit, tularik gene 1 |
| Synonyms | 1810044A24Rik, 2900005P22Rik, 4632408O18Rik, IBP, IKBKBBP, mKIAA1882, MRT13, NIBP, RGD1309461, T1, Tppc9, trafficking protein particle complex 9, trafficking protein particle complex subunit 9, TRS120, TRS130 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAPPC9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- schizophrenia
- autosomal recessive mental retardation type 13
- hereditary disorder
- COVID-19
- autosomal recessive nonsyndromic mental retardation
- sarcomatoid nasopharyngeal carcinoma
- sarcomatoid cancer
- nasopharyngeal cancer
- mental retardation
role in cell
- differentiation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAPPC9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- neuron differentiation
- cerebral cortex development
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- trans-Golgi network
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding