MLKL Gene Summary [Human]
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | MLKL |
| Official Name | mixed lineage kinase domain like pseudokinase [Source:HGNC Symbol;Acc:HGNC:26617] |
| Ensembl ID | ENSG00000168404 |
| Bio databases IDs | |
| Aliases | mixed lineage kinase domain like pseudokinase |
| Synonyms | 9130019I15Rik, hMLKL, LOC100364337, LOC687228, mixed lineage kinase domain-like, mixed lineage kinase domain like pseudokinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MLKL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- kinase-like domain
- ATP binding
- coiled-coil domain
- protein binding
- Protein kinase domain
- identical protein binding
- pseudo kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- binding protein
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
- MLKL_NTD
- four-helix bundle domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- cancer
- neoplasia
- acute-on-chronic liver failure
- chronic multifocal osteomyelitis
- ileitis
- hepatic steatosis
- liver damage
- non-small cell lung cancer
- colitis
role in cell
- cell death
- apoptosis
- activation in
- survival
- production in
- activation
- phosphorylation in
- necrosis
- damage
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MLKL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- necroptosis
- defense response to virus
- cell surface receptor signaling pathway
- protein homotrimerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell junction
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity