GLG1 Gene Summary [Human]
Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GLG1 |
| Official Name | golgi glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:4316] |
| Ensembl ID | ENSG00000090863 |
| Bio databases IDs | |
| Aliases | golgi glycoprotein 1 |
| Synonyms | CFR, CFR-1, CYSTEINE RICH FGF receptor, Esl, ESL-1, golgi apparatus protein 1, golgi glycoprotein 1, LOC146346, MG-160, Selectin endothelial cell ligand, Selel |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibroblast growth factor binding
- Cysteine rich repeat
- ectodomain
- receptor binding
Pathways
Biological processes and signaling networks where the GLG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- pancreatic cancer
- schizophrenia
- breast cancer
- ovarian cancer
- lung cancer
- liver cancer
- cervical cancer
- amyotrophic lateral sclerosis
- esophageal cancer
role in cell
- binding
- activation in
- function
- differentiation
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
- extracellular matrix
- Golgi cisternae
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein processing
- regulation of chondrocyte differentiation
- bone morphogenesis
- transforming growth factor beta receptor signaling pathway
- protein processing
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microtubule organizing center
- membrane
- Golgi membrane
- Golgi apparatus
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- fibroblast growth factor binding
- receptor binding