RNF181 Gene Summary [Human]
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Details
| Type | Retained Intron |
| Official Symbol | RNF181 |
| Official Name | ring finger protein 181 [Source:HGNC Symbol;Acc:HGNC:28037] |
| Ensembl ID | ENSG00000168894 |
| Bio databases IDs | |
| Aliases | ring finger protein 181 |
| Synonyms | 1700047F16Rik, 2500002L14Rik, 6230415N01Rik, HSPC238, ring finger protein 181 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF181 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- carcinoma in situ
- epithelial cancer in situ
role in cell
- growth
- proliferation
- expression in
- activation in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF181 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding