GREB1 Gene Summary [Human]
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GREB1 |
| Official Name | growth regulating estrogen receptor binding 1 [Source:HGNC Symbol;Acc:HGNC:24885] |
| Ensembl ID | ENSG00000196208 |
| Bio databases IDs | |
| Aliases | growth regulating estrogen receptor binding 1, gene regulated by estrogen in breast cancer |
| Synonyms | 5730583K22Rik, 9130004E13, Gene regulated by estrogen in breast cancer, gene regulated by estrogen in breast cancer protein, growth regulating estrogen receptor binding 1, KIAA0575, mKIAA0575, RGD1564091 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GREB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GREB1 N-terminal region
- GREB1 C-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometriosis
- breast carcinoma
- metastasis
- organismal death
- asthma
- neuroblastoma
- neuroblastoma formation
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- proliferation
- migration
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GREB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- nucleoplasm