PPIC Gene Summary [Human]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPIC |
| Official Name | peptidylprolyl isomerase C [Source:HGNC Symbol;Acc:HGNC:9256] |
| Ensembl ID | ENSG00000168938 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase C, cyclophilin C |
| Synonyms | Cyclophilin c, CyP-20c, CYPC, peptidylprolyl isomerase C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- cyclosporin A binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- alloxan-induced diabetic nephropathy
- diabetes mellitus
- hypertrophic scarring
role in cell
- number
- replication in
- migration
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein peptidyl-prolyl isomerization
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding