SEC61B Gene Summary [Human]
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SEC61B |
| Official Name | SEC61 translocon subunit beta [Source:HGNC Symbol;Acc:HGNC:16993] |
| Ensembl ID | ENSG00000106803 |
| Bio databases IDs | |
| Aliases | SEC61 translocon subunit beta |
| Synonyms | 1190006C12RIK, SEC61 beta, SEC61 translocon subunit beta, SEC61 translocon subunit β, SEC61 β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC61B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- Sec61beta family
- ribosome binding
- protein binding
- growth factor binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- rough endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC61B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- retrograde protein transport, ER to cytosol
- posttranslational protein targeting to membrane, translocation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum quality control compartment
- cytosol
- endoplasmic reticulum
- Sec61 translocon complex
- endoplasmic reticulum Sec complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- ribosome binding
- guanyl-nucleotide exchange factor activity
- epidermal growth factor binding