PRELID1 Gene Summary [Human]
This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | PRELID1 |
| Official Name | PRELI domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30255] |
| Ensembl ID | ENSG00000169230 |
| Bio databases IDs | |
| Aliases | PRELI domain containing 1, protein of relevant evolutionary and lymphoid interest, px19-like protein |
| Synonyms | 2610524G07Rik, CGI-106, PRELI, PRELI domain containing 1, PX19, RGD1308082, SBBI12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRELID1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid transporter
- protein binding
- transporter
- PRELI-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- STAT6
- phosphatidic acid
- endopeptidase
- reactive oxygen species
role in cell
- expression in
- production in
- apoptosis
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRELID1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- regulation of T cell differentiation
- negative regulation of mitochondrial membrane potential
- regulation of membrane lipid distribution
- negative regulation of release of cytochrome c from mitochondria
- regulation of mitochondrial membrane potential
- negative regulation of apoptotic process
- apoptotic process
- phospholipid transport
- positive regulation of T cell apoptotic process
- positive regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrion
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding