DCXR Gene Summary [Human]
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | DCXR |
| Official Name | dicarbonyl and L-xylulose reductase [Source:HGNC Symbol;Acc:HGNC:18985] |
| Ensembl ID | ENSG00000169738 |
| Bio databases IDs | |
| Aliases | dicarbonyl and L-xylulose reductase, short chain dehydrogenase/reductase family 20C, member 1, human carbonyl reductase 2, sperm surface protein P34H, kidney dicarbonyl reductase |
| Synonyms | 0610038K04Rik, 1810027P18Rik, DCR, dicarbonyl and L-xylulose reductase, dicarbonyl L-xylulose reductase, glb, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCXR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L-xylulose reductase
- 2-deoxy-D-gluconate 3-dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- SDR family mycofactocin-dependent oxidoreductase
- CH-OH group oxidoreductase
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- identical protein binding
- acetoin dehydrogenase
- sepiapterin reductase
- acetoin reductases
- short chain dehydrogenase
- NADH or NADPH:quinone oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- liver cancer
- overall survival
- non-insulin-dependent diabetes mellitus
- pentosuria
- hepatitis B virus-related hepatocellular carcinoma
regulates
- water
- 2,3-hexanedione
- 1,4-dibromobutanedione
- 3,4-hexanedione
- D-glucose
- isatin
- 2,3-heptanedione
- NADPH
- acetoin
- D-xylulose
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- cytoplasmic microtubule
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCXR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xylulose metabolic process
- NADP metabolic process
- glucuronate catabolic process to xylulose 5-phosphate
- glucose metabolic process
- positive regulation of reactive oxygen species metabolic process
- D-xylose metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- brush border
- microvillus
- cytosol
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- identical protein binding
- protein binding
- L-xylulose reductase (NADP+) activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor