Dcxr Gene Summary [Mouse]
Enables L-xylulose reductase (NADPH) activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate and glucose metabolic process. Acts upstream of or within NADP metabolic process and xylulose metabolic process. Located in brush border and microvillus. Is active in cytosol. Is expressed in adrenal gland; alimentary system; genitourinary system; respiratory system; and thymus. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dcxr |
| Official Name | dicarbonyl L-xylulose reductase [Source:MGI Symbol;Acc:MGI:1915130] |
| Ensembl ID | ENSMUSG00000039450 |
| Bio databases IDs | |
| Aliases | dicarbonyl L-xylulose reductase |
| Synonyms | 0610038K04Rik, 1810027P18Rik, DCR, dicarbonyl and L-xylulose reductase, dicarbonyl L-xylulose reductase, glb, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dcxr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L-xylulose reductase
- 2-deoxy-D-gluconate 3-dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- SDR family mycofactocin-dependent oxidoreductase
- CH-OH group oxidoreductase
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- identical protein binding
- acetoin dehydrogenase
- sepiapterin reductase
- acetoin reductases
- short chain dehydrogenase
- NADH or NADPH:quinone oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- liver cancer
- overall survival
- non-insulin-dependent diabetes mellitus
- pentosuria
- hepatitis B virus-related hepatocellular carcinoma
regulates
- water
- 2,3-hexanedione
- 1,4-dibromobutanedione
- 3,4-hexanedione
- D-glucose
- isatin
- 2,3-heptanedione
- NADPH
- acetoin
- D-xylulose
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- cytoplasmic microtubule
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dcxr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xylulose metabolic process
- NADP metabolic process
- glucuronate catabolic process to xylulose 5-phosphate
- glucose metabolic process
- positive regulation of reactive oxygen species metabolic process
- D-xylose metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- brush border
- microvillus
- cytosol
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- identical protein binding
- protein binding
- L-xylulose reductase (NADP+) activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor