GSTK1 Gene Summary [Human]
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | GSTK1 |
| Official Name | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] |
| Ensembl ID | ENSG00000197448 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase kappa 1 |
| Synonyms | 0610025I19Rik, DsbA-L, glutathione S-transferase kappa 1, glutathione S-transferase κ 1, GST, GST13, GST 13-13, GST class-kappa, GST class-κ, GSTK1-1, GSTkappa, hGSTK1, LOC51064 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DSBA-like thioredoxin domain
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- glutathione peroxidase
Pathways
Biological processes and signaling networks where the GSTK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin cancer
- insulin resistance
- androgenic alopecia
- glomerulonephritis
- microalbuminuria
- obesity
- urethritis
role in cell
- expression in
- phosphorylation in
- abnormal morphology
- multimerization in
- effacement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- mitochondrial matrix
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- glutathione metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- glutathione peroxidase activity
- glutathione transferase activity