TTK Gene Summary [Human]
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | TTK |
| Official Name | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] |
| Ensembl ID | ENSG00000112742 |
| Bio databases IDs | |
| Aliases | TTK protein kinase, cancer/testis antigen 96, monopolar spindle 1 kinase |
| Synonyms | CT96, ESK, Esk1, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- alpha helix
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- tetratricopeptide repeat
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- non-small cell lung cancer
- neoplasia
- metastasis
- epithelial neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- gastric cancer
- endometrial adenocarcinoma
role in cell
- expression in
- phosphorylation in
- growth
- proliferation
- apoptosis
- cell death
- signaling in
- invasiveness
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- centrosome
- chromosome
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- spindle organization
- mitotic spindle organization
- positive regulation of cell proliferation
- protein localization to kinetochore
- chromosome segregation
- female meiosis chromosome segregation
- peptidyl-serine phosphorylation
- meiotic spindle assembly checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- spindle
- kinetochore
Molecular Function
What the gene product does at the molecular level
- ATP binding
- kinetochore binding
- protein tyrosine kinase activity
- identical protein binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity