AHCYL1 Gene Summary [Human]
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | AHCYL1 |
| Official Name | adenosylhomocysteinase like 1 [Source:HGNC Symbol;Acc:HGNC:344] |
| Ensembl ID | ENSG00000168710 |
| Bio databases IDs | |
| Aliases | adenosylhomocysteinase like 1, inositol 1,4,5-trisphosphate receptor-binding protein, protein phosphatase 1, regulatory subunit 78 |
| Synonyms | 1110034F20Rik, ACHYL1, adenosylhomocysteinase-like 1, Ahcy-rs3, DCAL, IRBIT, PPP1R78, PRO0233, S-adenosylhomocysteine hydrolase-like 1, XPVKONA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AHCYL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- S-adenosyl-L-homocysteine hydrolase, NAD binding domain
- S-adenosyl-L-homocysteine hydrolase
- adenosylhomocysteinase
- enzyme
- protein binding
- enzyme regulator activity
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Alzheimer disease
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- uterine leiomyoma
- leiomyomatosis
role in cell
- apoptosis
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AHCYL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- S-adenosylmethionine cycle
- response to calcium ion
- apoptotic process
- angiotensin-mediated signaling pathway
- positive regulation of sodium ion transport
- epithelial fluid transport
- regulation of mRNA 3'-end processing
- protein export from nucleus
- regulation of ion transmembrane transporter activity
- one-carbon metabolic process
- regulation of anion transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- ER-mitochondrion membrane contact site
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- enzyme regulator activity
- adenosylhomocysteinase activity