NPAS2 Gene Summary [Human]
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NPAS2 |
| Official Name | neuronal PAS domain protein 2 [Source:HGNC Symbol;Acc:HGNC:7895] |
| Ensembl ID | ENSG00000170485 |
| Bio databases IDs | |
| Aliases | neuronal PAS domain protein 2 |
| Synonyms | bHLHe9, MOP4, neuronal PAS domain protein 2, PASD4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPAS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- transcription regulator
- nucleic acid binding
- heat shock protein binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- sequence-specific DNA binding
- PAS fold
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- organismal death
- hemangioma
- angiomatosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- essential tremor
- open-angle glaucoma
- prostate cancer
role in cell
- proliferation
- production in
- migration
- apoptosis
- oxygen consumption rate
- invasion by
- expression in
- pH
- homologous recombination repair in
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPAS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- response to redox state
- circadian regulation of gene expression
- central nervous system development
- positive regulation of behavioral fear response
- positive regulation of transcription, DNA-dependent
- response to xenobiotic stimulus
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- Hsp90 protein binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity