ZNF16 Gene Summary [Human]
The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Details
| Type | Protein Coding |
| Official Symbol | ZNF16 |
| Official Name | zinc finger protein 16 [Source:HGNC Symbol;Acc:HGNC:12947] |
| Ensembl ID | ENSG00000170631 |
| Bio databases IDs | |
| Aliases | zinc finger protein 16 |
| Synonyms | HZF1, KOX9, LOC100911090, zinc finger protein 16, Zinc finger protein 16 like, pseudogene 1, Znf16l-ps1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- Zinc-finger double domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cellular response to sodium dodecyl sulfate
- positive regulation of cell division
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- positive regulation of megakaryocyte differentiation
- positive regulation of kinase activity
- positive regulation of erythrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity