TRH Gene Summary [Human]
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | TRH |
| Official Name | thyrotropin releasing hormone [Source:HGNC Symbol;Acc:HGNC:12298] |
| Ensembl ID | ENSG00000170893 |
| Bio databases IDs | |
| Aliases | thyrotropin releasing hormone, prothyroliberin |
| Synonyms | Pro-TRH, THR, thyrotropin releasing hormone, TRF, TRH01 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thyrotropin-releasing hormone
- Thyrotropin-releasing hormone (TRH)
- protein binding
Pathways
Biological processes and signaling networks where the TRH gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- growth failure
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- Huntington disease
- survival
- hyperglycemia
- hypothyroidism
role in cell
- growth
- quantity
- activation
- binding in
- response
- expression in
- apoptosis
- migration
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- synaptic plasma membrane fractions
- cell surface
- secretory granules
- axons
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adult walking behavior
- signal transduction
- positive regulation of gamma-aminobutyric acid secretion
- cell-cell signaling
- negative regulation of glutamate secretion
- positive regulation of insulin secretion
- histamine metabolic process
- eating behavior
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- thyrotropin-releasing hormone activity