TRHR
TRHR Gene Summary
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | TRHR |
| Official Name | thyrotropin releasing hormone receptor [Source:HGNC Symbol;Acc:HGNC:12299] |
| Ensembl ID | ENSG00000174417 |
| Bio databases IDs | |
| Aliases | thyrotropin releasing hormone receptor |
| Synonyms | CHNG7,thyrotropin releasing hormone receptor,TRH-R1,TRH receptor |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- internalization targeting signal
- thyrotropin-releasing hormone receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
Pathways
Biological processes and signaling networks where the TRHR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TRH
- TRHR
- ARR3
- pGlu-3-Me-His-Pro-NH2
- beta arrestin
- EFNA5
- ACP2
- ARRB2
- NIPAL4
- IER3IP1
disease
- metabolic syndrome X
- nongoitrous congenital hypothyroidism type 7
- weight loss
- non-insulin-dependent diabetes mellitus
- hypothyroidism
regulated by
- MYB
- TRH
- CK2
- beta-estradiol
- tetradecanoylphorbol acetate
- Z-LLL-CHO
- ARRB1
- forskolin
- ionomycin
- IGSF1
regulates
- Ca2+
- MAPK3
- STAT3
- LEP
- MAPK
- TSHB
- KCNK3
- inositol phosphate
- MAPK1
- beta arrestin
role in cell
- expression in
- firing
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- Cytoplasm
- cell surface
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TRHR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- thyrotropin-releasing hormone receptor activity
- protein binding