KYAT1 Gene Summary [Human]
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KYAT1 |
| Official Name | kynurenine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:1564] |
| Ensembl ID | ENSG00000171097 |
| Bio databases IDs | |
| Aliases | kynurenine aminotransferase 1, glutamine transaminase K, kynurenine aminotransferase I, Glutamine--phenylpyruvate transaminase |
| Synonyms | 2010009K05Rik, CCBL1, GTK, KAT1, KATI, kynurenine aminotransferase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KYAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- tyrosine aminotransferase, eukaryotic
- kynurenine-oxoglutarate transaminase
- glutamine-phenylpyruvate transaminase
- cysteine-S-conjugate beta-lyase
- putative C-S lyase
- protein homodimerization
- AAT_I
- enzyme
- protein binding
- Aminotransferase class I and II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KYAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- kynurenine metabolic process
- biosynthetic process
- L-kynurenine catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- protein homodimerization activity
- glutamine-phenylpyruvate transaminase activity
- cysteine-S-conjugate beta-lyase activity
- kynurenine-oxoglutarate transaminase activity