Kyat1 Gene Summary [Rat]
Enables cysteine-S-conjugate beta-lyase activity and glutamine-phenylpyruvate transaminase activity. Involved in L-kynurenine catabolic process and pyruvate catabolic process. Located in cytosol and mitochondrion. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kyat1 |
| Official Name | kynurenine aminotransferase 1 [Source:RGD Symbol;Acc:1306912] |
| Ensembl ID | ENSRNOG00000016097 |
| Bio databases IDs | |
| Aliases | kynurenine aminotransferase 1 |
| Synonyms | 2010009K05Rik, CCBL1, GTK, KAT1, KATI, kynurenine aminotransferase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kyat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- tyrosine aminotransferase, eukaryotic
- kynurenine-oxoglutarate transaminase
- glutamine-phenylpyruvate transaminase
- cysteine-S-conjugate beta-lyase
- putative C-S lyase
- protein homodimerization
- AAT_I
- enzyme
- protein binding
- Aminotransferase class I and II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kyat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- kynurenine metabolic process
- biosynthetic process
- L-kynurenine catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- protein homodimerization activity
- glutamine-phenylpyruvate transaminase activity
- cysteine-S-conjugate beta-lyase activity
- kynurenine-oxoglutarate transaminase activity