HERC3 Gene Summary [Human]
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | HERC3 |
| Official Name | HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:4876] |
| Ensembl ID | ENSG00000138641 |
| Bio databases IDs | |
| Aliases | HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
| Synonyms | 5730409F18Rik, HECT and RLD domain containing E3 ubiquitin protein ligase 3, hect domain and RLD 3, mKIAA0032 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HERC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- HECTc
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- organismal death
role in cell
- expression in
- phosphorylation in
- proliferation
- binding in
- degradation in
- migration
- invasion by
- ubiquitination in
- K27 polyubiquitination in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endosomal compartment
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HERC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic vesicle