ZNF274 Gene Summary [Human]
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZNF274 |
| Official Name | zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068] |
| Ensembl ID | ENSG00000171606 |
| Bio databases IDs | |
| Aliases | zinc finger protein 274 |
| Synonyms | 2900024E01Rik, HFB101, NRIF, Nrif1, ZF2, Zfp110, zinc finger protein 110, zinc finger protein 274, ZKSCAN19, ZSCAN51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF274 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- neurotrophin p75 receptor binding
- leucine rich region
- krueppel associated box
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- SCAN domain
- chromatin binding
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial ovarian cancer
- ovarian carcinoma
role in cell
- apoptosis
- survival
- cell death
- growth
- cell division
- cell cycle progression
- signaling in
- transport in
- elongation
- action in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF274 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity