LGALS4 Gene Summary [Human]
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | LGALS4 |
| Official Name | galectin 4 [Source:HGNC Symbol;Acc:HGNC:6565] |
| Ensembl ID | ENSG00000171747 |
| Bio databases IDs | |
| Aliases | galectin 4 |
| Synonyms | GAL4, Galectin-4, L-36, L36LBI, L36LBP, lectin, galactose binding, soluble 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal carbohydrate recognition domain
- DNA binding domain
- N-terminal carbohydrate recognition domain
- protein binding
- carbohydrate binding
- GLECT
- galactoside binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- Crohn disease
- metastatic colorectal cancer
- chronic colitis
- primary prostate cancer
role in cell
- cell death
- apoptosis
- adhesion
- exposure in
- activation
- interaction
- cell cycle progression
- cell-cell adhesion
- polarization in
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- cellular membrane
- Plasma Membrane
- cytosol
- apical cytoplasm
- apical cell surfaces
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- antibacterial peptide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- galactoside binding
- carbohydrate binding