ADRA1D Gene Summary [Human]
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADRA1D |
| Official Name | adrenoceptor alpha 1D [Source:HGNC Symbol;Acc:HGNC:280] |
| Ensembl ID | ENSG00000171873 |
| Bio databases IDs | |
| Aliases | adrenoceptor alpha 1D |
| Synonyms | [a]1d, ADRA1, ADRA1A, ADRA1R, Adrd1, adrenergic receptor, alpha 1d, adrenergic receptor, α 1d, adrenoceptor alpha 1D, adrenoceptor α 1D, ALPHA1, Alpha1d adrenoceptor, alpha1D-AR, DAR, dJ779E11.2, Gpcr8, Spr8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADRA1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- alpha1-adrenergic receptor
Pathways
Biological processes and signaling networks where the ADRA1D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- disorder of coronary artery
- cardiovascular death
- cardiovascular disorder
- acute coronary syndrome
- insulin resistance
- metabolic syndrome X
- stroke
- myocardial infarction
role in cell
- activation in
- apoptosis
- production in
- proliferation
- generation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADRA1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adenylate cyclase-activating adrenergic receptor signaling pathway
- positive regulation of cell proliferation
- positive regulation of vasoconstriction
- cell-cell signaling
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- alpha1-adrenergic receptor activity